Anyone know if this is possible, or what level of difficulty is involved? Any way to determine the compression ratio, possible piston/valve interference, etc?

the engines are similar, both vtec, both same bore and a lot of similarities, but I know small differences can make a huge difference. Thanks.

 

I just replied to your PM. Yes, it will bolt up. I didn't know there was a compression difference, but according to the calculator it raises the compression a tad bit. Nothing I would worry about though.
http://www.knology.net/~jediklc/D.htm
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u need y8 head bolts

 

it will bolt up fine. but some people say that the z6 is a better head because it revs a little higher. and flows better in the topend.